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These may include: Cocaine, amphetamine, modafinil, butylone, MDPV, methylone (combination being known as "Bubbles"), metamfepramone, alcohol, gammbutyrolactone/gamma hydroxybutyrate benzodiazepines, kratom (mytraginin), heroin, cannabis, ketamine (combination being known as "challenge"), MDMA, 1-Benzylpiperazine, 3-trifluoromethylphenylpiperazine, dimethylamylamine, and sildenafil.Mephedrone is used for its stimulant and entactogenic properties.Consumption of synthetic cathinones result in typical stimulant-related subjective effects like increased alertness, awareness and energy, euphoria, sociability and talkativeness, intensification of sensory experiences, sexual arousal, reduced appetite, and insomnia.Commonly reported adverse effects of mephedrone use include altered mental status (agitation, paranoid delusions, hallucinations, panic attacks, self-mutilation, suicide attempts, and homicidal activity), irritability, inability to concentrate, short-term memory deficits, tachycardia, hypertension, chest pain, hyperthermia, diaphoresis, bruxism, nasal irritation, and nosebleeds from insufflation of the powder, tremors, seizures, dilated pupils, blurred vision, dry mouth/thirst, vomiting, anorexia, weight loss, cardiac arrest, and death.
Mephedrone is a synthetic ring-substituted cathinone closely related to the phenethylamine family, differing only by a keto functional group at the beta carbon. As it is a cathinone derivative with affiliation to beta-keto amphetamines, mephedrone is expected to act as a central nervous system stimulant by promoting the release of monoamine neurotransmitters and likely inhibiting their reuptake.
There are large numbers of HIV-positive men in this subpopulation, the majority of whom share needles to inject and have unprotected sex with several partners.
Treatment for patients intoxicated with synthetic cathinones is mostly supportive care.
In addition, several other effects may be associated with intoxication by cathinones, including hyponatremia, hyperkalemia, metabolic acidosis, acute kidney injury and urinary retention, rhabdomyolysis, compartment syndrome, acute liver failure, cardiomyopathy, disseminated intravascular coagulation, catatonia, necrotizing fasciitis, and serotonin syndrome.
who use the drug solely to facilitate sex and has alarming health consequences such as increased spread of HIV and other sexually transmitted infections.